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KMID : 0882420170920010094
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Korean Journal of Medicine
2017 Volume.92 No. 1 p.94 ~ p.98
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A Case of Methemoglobinemia Caused by Primaquine
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Lee Jae-Yong
Kim Sung-Han
An Su-Jong
Oh Hye-Seon
Yi Sang-Young
Lee Hoon-Hee
Han Duck-Jong
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Abstract
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Primaquine is often administered for the hypnozoite stage of Plasmodium vivax and Plasmodium ovale. Primaquine (with clindamycin) is also an alternative drug for treatment of pneumocystis pneumonia when trimethoprim/sulfamethoxazole cannot be used. Primaquine may cause methemoglobinemia, an altered state of hemoglobin in which the ferrous state of heme is oxidized to the ferric state. We report a case of methemoglobinemia caused by a standard dose of primaquine plus clindamycin in a 27-year-old female recipient of a kidney transplant who was diagnosed with pneumocystis pneumonia.
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KEYWORD
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Methemoglobin, Methemoglobinemia, Primaquine
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